Texas Children’s Hospital

public announcement

Name: Texas Children’s Hospital

Phone: 832-822-3950

Address: 6701 Fannin Street, Suite 1230.01, Houston, TX 77030

Number of CCM outpatients seen in 2023: 53

Number of inpatient CCM patient days in 2023: 116

Number of CCM research publications in last 5 years: 5

faculty

Medical Director: Samuel G. McClugage III, MD

Nurse Coordinator: Allison Brayton, RN

Cerebrovascular Neurosurgeon: Samuel G. McClugage III, MD

Pediatric Neurologist: Daniel Davila-Williams, MD

Epileptologist: Daniel Davila-Williams, MD

Geneticist: Ionela Iacobas, MD

Radiologist: Nilesh Desai, MD

Additional Faculty:

Genetic Counselor: Hannah Helber, MS, CGC

Research Coordinator: Sarah Martinez, MPH

Pediatric Epilepsy Surgery: Howard Weiner, MD

Pediatric Stroke Rehabilitation: Christian Niedzwecki, DO

Neurosurgery: Guillermo Aldave, MD, Ph.D and Howard Weiner, MD

Neurology: Gary D. Clark, MD

Vascular Anomalies/Genetics: Netta Schneller, MD

Research

Texas Children’s Hospital has a number of clinical and translational research projects on-going which focus on pediatric cerebral cavernous malformations. The Neurological Research Institute (NRI) at Texas Children’s Hospital and Baylor College of Medicine represent some of the foremost genetic research facilities and programs in the world. To that end, they have an on-going clinical/translational IRB-approved project evaluating the genetic mutations associated with the development of pediatric cerebral cavernous malformations. The purpose is to identify novel somatic genetic mutations in sporadic/non-familial cerebral cavernous malformation (CCM) patients, which will allow them to identify novel genetic treatment targets for future therapeutics.

As part of this project and for use in future research studies, they have a tissue bank storing samples from pediatric cavernous malformation patients that have undergone surgical resection and consented to participate in the tissue bank. This tissue bank allows them to perform the genetic analyses on a large number of patients with sporadic non-familial CCM, helping them to find novel somatic mutations.

They also have a program to identify human cell-type specific viral vectors, including in cavernous malformation patients, to help identify treatment pathways for future gene therapy treatments.

The neurovascular program at Texas Children’s Hospital manages an on-going clinical database and prospective clinical trial monitoring clinical outcomes in patients with pediatric cerebral cavernous malformations.

patient education and support

Texas Children’s Hospital has dedicated webpages to learn more about CCM and the neurovascular clinic.

Last Updated: 2.19.2024